发明名称 |
MHC-peptide labelled conjugates |
摘要 |
<p>The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X<1>MHC<2>-peptide (1) or MHC<2>peptide<1>X (2), wherein X represents a labelling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen; <1> represents a covalent bond or a bivalent linker bound to X and MHC in formula (1) or to X and peptide in formula (2) by covalent bonds; and <2> represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to monitor the therapy of autoimmune diseases. <IMAGE></p> |
申请公布号 |
EP0742014(A1) |
申请公布日期 |
1996.11.13 |
申请号 |
EP19950117141 |
申请日期 |
1989.06.23 |
申请人 |
BIOSPAN CORPORATION |
发明人 |
SHARMA, SOMESH D.;CLARK, BRIAN R.;LERCH, L. BERNARD |
分类号 |
G01N33/564;A61K35/12;A61K35/28;A61K39/00;A61K45/00;A61K47/48;A61K49/00;A61K51/08;A61K51/12;A61P37/06;C07K14/435;C07K14/705;C07K14/74;C07K14/78;C07K17/06;C07K19/00;C12N15/00;C12N15/09;C12P21/00;C12R1/91;G01N33/50;(IPC1-7):A61K47/48 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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