NEISSERIAL VACCINES

摘要

This invention relates to mutants of Neisseria useful for vaccine preparation. Specifically this invention relates to mutants of Neisseria containing mutations in a major outer membrane protein gene such that no immunologically functional polypeptides encoded by said gene are produced. More specifically, the invention relates to a mutant strain of Neisseria gonorrhoeae or Neisseria meningitidis having a mutation of the PIII gene or Class 4 gene respectively and to vaccines derived therefrom.