| 摘要 |
The present invention relates to compounds of the formula: <IMAGE> I wherein R is H or alkyl; Y1 is -CH= or -N=; and Y2 -CH=, -C(OH)=, -C(NO2)=, -C(NH2)=, -C(Hal)=, -N=; X is cycloalkenyl; bicyclo[2.2.1]hept-2-yl, optionally substituted by phenyl-2-oxo-5 -methoxymethyl-oxazolidinyl; bicyclo[2.2.1]-hept-5 -en-2-yl; adamantyl; or cycloalkyl or piperidinyl, optionally substituted by amino, alkyl, -CN, oxo hydroxyimino, ethylenedioxy or by -OR1, R1 is -CH(C6H5)2, -(CH2)nC6H5, alkyl, H, -(CH2)nNHCOCH3, -(CH2)nNH2, -(CH2)nCN, -(CH2)nSCH3-(CH2)nSO2CH3, -CO-lower-alkyl, -COC6H5, optionally substituted by oxazolidine; or by =CR2R3, R2 is alkyl R3 is H, -CN, alkyl, phenyl or COO-alkyl; or by -(CH2)nR4 R4 is -CN, amino, -NHCOCH3, -COC6H5Hal, phenyl or hydroxy; or by -COR5, R5 is alkyl, -CH=CH-C6H5, -C6H5, -C6H5CF3 or -O-alkyl; or by -NR6R7, R6 is or -COCH3; R7 is -COCH3, benzyl or -(CH2)nNHCOC6H4Hal; and n is 1-3; These can be used for the prevention or control of depressive, panic and anxiety states, and treatment of certain cognitive disorders and neurodegenerative diseases.
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