| 发明名称 |
Cells expressing high levels of CD59 |
| 摘要 |
A method and means for protecting cells and transplanted organs for the effects of activated complement proteins generated in blood serum or plasma by introducing the gene for CD59 into the cells to be protected is described. In an example of the method, protection against the pore-forming activity of the human C5b-9 proteins was conferred on CHO cells by transfection with cDNA encoding the human complement regulatory protein CD59.
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| 申请公布号 |
US5573940(A) |
申请公布日期 |
1996.11.12 |
| 申请号 |
US19940271562 |
申请日期 |
1994.07.07 |
| 申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION;YALE UNIVERSITY |
发明人 |
SIMS, PETER J.;BOTHWELL, ALFRED L. M. |
| 分类号 |
A61K35/12;A61K38/00;A61K38/17;A61K48/00;A61L27/50;C07K14/47;C07K14/705;C07K14/74;C07K14/745;C07K16/18;C07K16/28;C07K16/30;C07K16/36;C12N15/85;(IPC1-7):C12N5/10 |
主分类号 |
A61K35/12 |
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