发明名称 |
PREPARATION OF ESSENTIALLY ISOMERICALLY PURE METHYL E-2-(2-ARYLOXYMETHYLENE-PHENYL) CROTONATES, AND INTERMEDIATES THEREFOR |
摘要 |
A process for preparing substantially isomer-pure E-2-(2-aryloxymethylene phenyl)-crotonic acid methyl esters having formula (Ia), in which R stands for an aromatic residue substitued by the usual groups and R' stands for a C1-C3 alkyl group, is characterised in that a corresponding 2-(2-aryloxymethylene phenyl)-.alpha.-keto-acetic acid methyl ester having formula (II) with an alkyl metal compound having formula (III), in which M stands for a metal ion equivalent, first yields the corresponding 2-(2-aryloxymethylene phenyl).alpha.-hydroxybutyric acid methyl ester having formula (IV), which is then dehydrated in the presence of an acid into a mixture of E- et Z-2-(2-aryloxymethylene phenyl)-crotonic acid methyl esters having formulas (Ia) and (Ib). This mixture is finally converted into the substantially isomer-pure E-2- (2-aryloxymethylene phenyl)-crotonic acid methyl ester (Ia) in the presence of a base in an inert polar solvent.
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申请公布号 |
CA2217331(A1) |
申请公布日期 |
1996.11.07 |
申请号 |
CA19962217331 |
申请日期 |
1996.04.23 |
申请人 |
BASF AKTIENGESELLSCHAFT |
发明人 |
GRAMMENOS, WASSILIOS;OBERDORF, KLAUS;SAUTER, HUBERT;G TZ, NORBERT |
分类号 |
C07C67/327;C07C67/333;C07C67/343;C07C69/734;(IPC1-7):C07C69/734;C07C253/30;C07C255/54;C07C319/20;C07C323/19 |
主分类号 |
C07C67/327 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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