| 摘要 |
A compound of general formula (I) in which R is (a); wherein R.alpha. is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; R.beta. is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; or R.alpha. and R.beta. together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms; R1 is (C1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a readily removable hydroxy protecting group, or by an amino group which is optionally protected by a readily removable amino protecting group; R2 is hydrogen or methyl; and R3 is selected from the group consisting of (a) a group of formula (i) wherein R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen, (C1-6)alkyl optionally substituted by halogen, (C1-6)alkenyl, (C1-6)alkoxycarbonyl, aryl, or heteroaryl, R3 is hydrogen, (C1-6)alkyl, or (C1-6)alkoxycarbonyl, and R4 is a pharmaceutically acceptable ester forming group, and (b) a group of formula CH(Ra)O.CO.Rb, wherein Ra is hydrogen, (C1-6)alkyl, (C3-7)cycloalkyl, methyl, or phenyl; and Rb is (C1-6)alkyl(C3-7)cycloalkyloxy or (C1-6)alkoxy(C1- 6)alkyl, is useful in the treatment of bacterial infections.
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