| 发明名称 |
LOW OXYGEN AFFINITY MUTANT HEMOGLOBIN |
| 摘要 |
A non-naturally occurring mutant hemoglobin ( alpha 96Val}Trp) is provided that has a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. The mutant hemoglobin is preferably obtained by recombinant DNA techniques. Such a mutant hemoglobin may be used as a component of a blood substitute.
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| 申请公布号 |
WO9634974(A1) |
申请公布日期 |
1996.11.07 |
| 申请号 |
WO1996US06075 |
申请日期 |
1996.04.30 |
| 申请人 |
CARNEGIE MELLON UNIVERSITY |
发明人 |
HO, CHIEN;KIM, HYUN-WON;SHEN, TONG-JIAN |
| 分类号 |
C12N15/09;A61K38/00;A61K38/16;A61P7/08;C07K14/805;C12N1/21;C12P21/02;C12R1/19;(IPC1-7):C12P21/06;C12N1/10;C12N15/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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