发明名称 |
MODULATION OF BCL-2 PHOSPHORYLATION |
摘要 |
Methods of identifying compounds that modulate bcl-2 mediated cell death are disclosed. The methods comprise contacting a cell or cell extract with a test compound and detecting the level of bcl-2 phosphorylation compared to the level of bcl-2 phosphorylation in a similar cell or cell extract not contacted with the test compound. Methods of treating an individual susceptible to or suffering from a disease characterized by inhibition of apoptosis are disclosed. The methods comprise administering to such an individual a bcl-2 phosphorylation compound that inhibits dephosphorylation of bcl-2 and/or facilitates phosphorylation of bcl-2. Methods of treating an individual susceptible to or suffering from a disease characterized by apoptosis are disclosed. The methods comprise administering to such an individual a bcl-2 dephosphorylation compound that inhibits phosphorylation of bcl-2 and/or facilitates dephosphorylation of bcl-2.
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申请公布号 |
WO9635124(A1) |
申请公布日期 |
1996.11.07 |
申请号 |
WO1996US06248 |
申请日期 |
1996.05.03 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
CROCE, CARLO, M.;HALDAR, SUBRATA |
分类号 |
A61K31/337;A61K31/35;G01N33/50;(IPC1-7):G01N33/574;G01N33/573;A61K47/00 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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