2-UREIDO-BENZAMIDE DERIVATIVES

摘要

This invention is concerned with 2-ureido-benzamide compounds of formula (1), in which R1 is H, halogen, alkyl, alkoxy or dialkylamino and R2 is H, halogen, hydroxy, nitro, alkyl, alkoxy, cycloalkylmethoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or formula (II), wherein j, R3 and R4 are defined as indicated in the disclosure; X is an alkyl, cycloalkyl, cycloalkylmethyl, alkoxyalkyl or formula (III), wherein k, R5 and R6 are defined as indicated in the disclosure; and Y is H or alkyl and Z is formula (IV), (V) or (VI), wherein m is an integer of from 0 to 4, and (VII), A1 and A2 are defined as indicated in the disclosure, or -NYR can form a ring; and pharmaceutically acceptable acid addition salts thereof. These compounds are useful as ACAT inhibitors.