| 摘要 |
<p>An object of the present invention is to offer a peptide fragment which is useful as a pharmaceutical agent, etc. In the peptide fragment of the present invention, a 1-29 amino acid residue peptide fragment of aFGF in which cysteine, an amino acid at 16-position, was substituted with another amino acid. In the passive avoidance learning test and the maze-learning test in water, the peptide of the present invention was confirmed to exhibit an excellent action of improving the learning and the remembering of the senility-accelerated mice in which remembering and learning abilities were reduced. The peptide fragments have also the protecting effects against the death of cerebral neurons caused by ischemia. As such, the substance of the present invention shows excellent improving actions to brain functions and protecting cerebral neurons. Accordingly, said substance is useful as a pharmaceutical agent against dementia and other diseases caused by reduction of various brain functions.</p> |
