| 发明名称 |
Soluble polypeptidic fragments of lag-3 protein method of production thereof therapeutic composition anti-idiotype antibodies |
| 摘要 |
Soluble polypeptide fraction consisting of all or part of one at least one of the four immunoglobulin-type extracellular LAG-3 protein domains (amino acids 1-159, 160-230, 240-330 and 331-412 of the SEQ ID NO:1 sequence) or consisting of one peptide sequence derived from these domains by replacement, addition or deletion of one or more amino acids. The fraction of the invention has a specificity at least equal to that of LAG-3 in relation to its ligand. |
| 申请公布号 |
ZA9503629(B) |
申请公布日期 |
1996.11.05 |
| 申请号 |
ZA19950003629 |
申请日期 |
1995.05.05 |
| 申请人 |
INSTITUT GUSTAVE ROUSSY;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
FLORENCE FAURE;THIERRY HERCEND;BERTRAND HUARD;FREDERICK TRIEBEL |
| 分类号 |
C12N15/09;A61K38/00;A61K38/17;A61K39/395;A61P37/06;C07K14/705;C07K16/28;C07K16/42;C07K19/00;C12N15/12;C12P21/02;C12P21/08;C12R1/91 |
主分类号 |
C12N15/09 |
| 代理机构 |
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