Glycosphingolipids with a group capable of coupling in the sphingoid portion, the preparation and use thereof

摘要

The invention relates to the chemical modification of the sphingoid portions of glycosphingolipids. It has been possible by a series of reactions to introduce an amino group in the position of the carbon double-bond in the sphingoid portion after elimination of the long-chain aldehyde. Glycosphingolipids of the formula (2) and (3), where X and Y denote a group capable of coupling, are suitable for coupling to other molecules, preferably proteins. X preferably represents NH2, and Y preferably represents <IMAGE> <IMAGE> (2) <IMAGE> (3)