MATRIX-BEARING TARGETS FOR MALDI MASS SPECTROMETRY AND METHODS OF PRODUCTION THEREOF

摘要

The present invention provides new methods for producing substantially continuous, homogeneous layers of MALDI (matrix-assisted laser desorption/ionization) matrix materials deposited on MALDI targets which are substantially free of voids and large crystals. The methods involve the deposition of MALDI matrix materials in a nebulized spray (41) which is enveloped in a sheath of non-reactive gas (71) which confines and entrains the spray and aids in the evaporation of the solvent such that substantial, if not complete, solvent evaporation occurs before the matrix material is deposited on the target surface (10). The invention further provides such matrix layers (20) and preformed matrix-bearing targets for use in MALDI mass spectrometry.