Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs

摘要

Heterocyclic compounds, characterised in that they correspond to the general formula I …… in which … …  Ar represents a nitrogenous or non-nitrogenous aromatic radical, chosen from the variously substituted aryls, 2-pyrimidine, 2-(N-methyl)imidazole and 3-(1,2-benzisotriazole) …  n can have the values 1 to 6 …  Z1 represents a nitrogen atom or a group C-R1 …  Z2 represents a nitrogen atom or a group C-R2 …  Z4 represents a nitrogen atom or a group C-R4 …  Z5 represents a nitrogen atom or a carbon atom …  Z6 represents a substituted or unsubstituted aza group or methylene group, …  provided that when Z5 represents a nitrogen atom, Z6 is a substituted or unsubstituted methylene group, and that when Z5 is a carbon atom, Z6 is a substituted or unsubstituted aza group, …  and R1, R2, R3 and R4, which are identical or different, also being able to form a part of another aromatic or non aromatic ring, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxyl radical, a carboxyl radical, a carboxamido radical, an alkyloxycarbonyl radical or an aryl or substituted aryl radical, …  and when Ar is 2-pyrimidine and Z6 is a substituted or unsubstituted methylene group, the assembly Z1, Z2, Z4 and Z5 forms an aromatic heterocycle, chosen from the group comprising the trisubstituted imidazole, the substituted or unsubstituted benzimidazole and the substituted or unsubstituted imidazopyridine radical, … and their addition salts with pharmaceutically acceptable acids, except for the compounds for which Ar is a substituted or unsubstituted phenyl, Z5 and Z2 each represent a nitrogen atom, Z1 represents a group C-R1 and Z4 a group C-R4, and R3-R4 form a part of another aromatic ring.