发明名称 |
PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION |
摘要 |
The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention perform platelet aggregation action without remarkable elongation of hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity. Compounds of this invention are piperazinones of formula (I) wherein A<1> and A<2> independently are a proton-accepting group or a group convertible into the proton-accepting group; D is a spacer having a 2 to 6 atomic chain optionally bonded through a hetero-atom and/or a 5- or 6-membered ring (provided that the 5- or 6-membered ring is, depending on its bonding position, counted as 2- or 3-atomic chains); R<1> is hydrogen atom or a hydrocarbon group; R<2> is hydrogen atom or a residual group formed by removing -CH(NH2)COOH from an alpha-amino acid, or R<1> and R<2> may be combined to form a 5- or 6-membered ring; P is a spacer having a 1- to 10- atomic chain optionally bonded through a hetero-atom and/or a 5- or 6-membered ring (provided that the 5- or 6-membered ring is, depending on its bonding position, counted as 2- or 3-atomic chains); Y is an optionally esterified or amidated carboxyl group; and n is a number ranging 0 to 8, and salts thereof. |
申请公布号 |
WO9633982(A1) |
申请公布日期 |
1996.10.31 |
申请号 |
WO1996JP01139 |
申请日期 |
1996.04.25 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;FUKUSHI, HIDETO;NAKA, TAKEHIKO;TERASHITA, ZEN-ICHI;MIYAWAKI, TOSHIO |
发明人 |
FUKUSHI, HIDETO;NAKA, TAKEHIKO;TERASHITA, ZEN-ICHI;MIYAWAKI, TOSHIO |
分类号 |
C07D241/08;C07D405/12;C07D413/12;C07D413/14 |
主分类号 |
C07D241/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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