| 发明名称 |
ANTAGONISTS OF HUMAN INTERLEUKIN-6 THAT ARE TOTALLY INCAPABLE OF BINDING GP 130, AND THEIR USE IN THE PREPARATION OF PHARMACEUTICAL COMPOUNDS |
| 摘要 |
The present invention relates to antagonists of human interleukin-6 that are totally incapable of binding the receptor chain responsible for transduction of the signal associated with this cytokine, that is to say with gp 130. The figure shows the lack of interaction between human interleukin-6 antagonists according to the invention and the protein gp 130.
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| 申请公布号 |
WO9634104(A1) |
申请公布日期 |
1996.10.31 |
| 申请号 |
WO1996IT00084 |
申请日期 |
1996.04.26 |
| 申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANG;CILIBERTO, GENNARO;SAVINO, ROCCO;PAONESSA, GIACOMO |
发明人 |
CILIBERTO, GENNARO;SAVINO, ROCCO;PAONESSA, GIACOMO |
| 分类号 |
C12N15/02;A61K38/00;A61K48/00;A61P3/02;A61P19/10;A61P29/00;A61P35/00;A61P37/00;A61P37/02;A61P43/00;C07K14/54;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/24;C12P21/02;(IPC1-7):C12N15/24;A61K38/20 |
主分类号 |
C12N15/02 |
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