MODIFIED POLYPEPTIDES FOR ENHANCED IMMUNOGENICITY

摘要

The invention relates to a recombinant polypeptide showing enhanced immunogenicity, comprising a glycosyl-phosphatidylinositol structure. The polypeptide is for example an antigen, such as a parasite polypeptide, in particular a Plasmodium falciparum polypeptide, such as the circumsporozoite protein (CSP). The invention further relates to a recombinant DNA vector for expressing the polypeptide, methods of inducing an immune response directed to one or more epitopes of the polypeptide, and methods for the production of the modified polypeptides vaccines, comprising the polypeptide.