LHRH analogs and congeners with high water solubility have been synthesized. These new analogs had 0 %-100 % antiovulatory activity at a 0.5 mu g dosage and 0 %-80 % at 0.25 mu g. The ED50 for histamine release was 30.5 mu g/ml- > 300 mu g/ml.
申请公布号
WO9633729(A1)
申请公布日期
1996.10.31
申请号
WO1996US05682
申请日期
1996.04.26
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
