SYNTHESIS OF (S)-3-(2-THIENYLTHIO) BUTYRIC ACID AND ANALOGS
摘要
This invention is concerned with an improved process for the synthesis of and intermediate en route to 5,6-dihydro-(s)-4-(ethylamino)-(s)-6-methyl-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related compounds. The instant process reduces the reaction time for the synthesis of the key intermediate from 3 to 4 days to from about 2 to about 4 hours while retaining the high enantiomeric purity of the product.
申请公布号
WO9633990(A1)
申请公布日期
1996.10.31
申请号
WO1996US05623
申请日期
1996.04.22
申请人
MERCK & CO., INC.;MATHRE, DAVID, J.;SOHAR, PAUL;BROWN, LYNN, MAY