| 摘要 |
PURPOSE: To obtain the subject new compound by culturing a fungus belonging to the genus Penicillium, capable of producing a physiologically active substance NK374,186 analog, having inhibitory action on proliferation of cell and controlling action on blastgenesis of lymphocyte, useful as an antitumor agent, immunomodulating agent, etc. CONSTITUTION: A new NK374186 analog (salt) of the formula [one of (m) and (n) is 1 and the other is 0; R is a 13C alkyl; P1 is hydroxyl group or phosphate group; A1 is CH-CH(CH3 )-X1 (X1 is OH, an inorganic acid group or a 1-7C organic acid group) or C=CH-CH3 ; A2 is CHCH2 X2 (X2 is shown as X1 ) or C=CH2 ]. This compound has inhibitory action on proliferation of cell and controlling action on blastgenesis of lymphocyte and is useful as an antitumor agent, immunomodulating agent, etc. The compound is obtained by culturing a fungus [e.g. Penicillium NK374186 strain (FERM P-12,285), etc.] belonging to the genus Penicillium, capable of producing the physiologically active substance NK374,186 analog in a medium and collecting the product from the culture product. |
