发明名称 |
RNA import elements for transport into mitochondria |
摘要 |
The invention relates to small RNAs encoded within the nucleus of mammalian cells that specifically import to the mitochondria. The RNAs bind to several nucleolar peptides and thus provide potential carriers for import of biological molecules, including metabolites and proteins, into the mitochondrial compartment. Mitochondrial dysfunction in several maternally inherited human diseases may be correctable employing linkage of mitochondrial import signal to mitochondrial tRNA sequences expressed from nuclear trans-genes without requirement for direct genetic transformation of mitochondria.
|
申请公布号 |
US5569754(A) |
申请公布日期 |
1996.10.29 |
申请号 |
US19930076094 |
申请日期 |
1993.06.11 |
申请人 |
BOARD OF REGENTS, UNIVERSITY OF TX SYSTEMS |
发明人 |
WILLIAMS, R. SANDERS;LI, KANG |
分类号 |
C12N9/22;C12N15/85;(IPC1-7):C07H21/02;C07H21/04;C12N15/70 |
主分类号 |
C12N9/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|