| 摘要 |
FIELD: organic chemistry. SUBSTANCE: product: derivatives of oxazolidine-2-one of the general formulawhere R - hydrogen or lower alkyl; X - cycloalkenyl; bicyclo[2,2,1]hept-2-yl substituted at definite conditions with phenyl-2-oxo-5-methoxymethyloxazolidinyl; bicyclo[2,2,1] hept-5-ene-2-yl; adamantyl; or cycloalkyl or piperidine mono- or multisubstituted at definite conditions with halogen, amino, lower alkyl, nitrile, oxo-group, hydroxyimino, ethylenedihydroxy or -ORwhere R- -CH , - CH,, lower alkyl, hydrogen,, -CO-lower alkyl, -COCH, substituted at definite conditions with oxazolidinyl-group; or substituted with =CRR, where R- hydrogen or lower alkyl; R- hydrogen, nitrile, lower alkyl, phenyl or COO-lower alkyl; or substituted with - R, where R- nitrile, amino, -NHCOCH, -COCH-гал,, phenyl or hydroxyl-group; or substituted with -COR, where R- lower alkyl, -CH=CH--CH,, -CHCF, -O-C or -O-lower alkyl; or substituted with -NRRwhere R- hydrogen or -COCH;; R- -COCH,, benzyl or - NHCOCHгал;; n = 1-3; Y- -CH= or -N= ; Y- -CH= , -C(OH)=, -C(NO)=, -C(NH)=, -C(hal)= or -N=, and also pharmaceutically acceptable salts of basic compounds of the formula (I)with acids. New synthesized compounds and their pharmaceutically acceptable salts can be used in neurology (Parkinsons and Alzheimer diseases, depression prevention, brain function disorders and others). EFFECT: improved method of synthesis. |
