| 摘要 |
FIELD: organic chemistry. SUBSTANCE: new indoline-derivatives of the formula (I)where: Ris C-C-alkyl or -NRR; Rand R, means independently hydrogen or C-C--alkyl; Ris C-C--cycloalkyl, C-C--cycloalkylalkyl, arylhydroxy-C-C--alkyl, arylthio-C-C--alkyl, arylamino--C-C--alkyl, arylsuldinyl--C-C--alkyl, aryl, aryl-C-C--alkyl, arylhydroxyaryl-C-C--alkyl or arylthio-C-C--alkyl. Aryl-groups indicated in above mentioned arylhydroxyalkyl, arylthioalkyl, arylaminoalkyl, arylsulfinylalkyl, aryl, arylalkyl, arylhydroxyarylalkyl and arylthioarylalkyl can be substituted with any (up to maximal) amounts of substituents taken independently from the group involving: halogen, , cyano, C-C--alkyl, C-C--alkenyl, C-C--alkoxy, C-C--alkenylhydroxy, C-C--alkoxyalkyl, halogen-substituted C-C--alkyl, halogen-substituted C-C--alkoxy-group, C-C--alkoxycarbonyl, aminocarbonyl, and C-C--alkylthio; A means C-C--alkylene, C-C--alkenylene, or -O-(CH); Y means independently halogen, halogen-substituted C-C--alkyl, C-C--alkyl, C-C--alkenyl, C-C--alkoxy-group, or C-C--alkenylhydroxy-group; m = 2,3 or 5; n = 0, 1, 2 or 3. Under condition that substituent Y and binding group A were bound with aromatic ring. Synthesized compounds can be used as an active component in pharmaceutical compositions for treatment or attenuation of inflammatory, allergic or cardiovascular sickness in mammalian. Synthesized compounds show capability to inhibit 5-lipoxygenase activity. EFFECT: improved method of synthesis. |
