BIOLOGICALLY ACTIVE PEPTIDES AND COMPOSITIONS, THEIR USE

摘要

Compounds of general formula (I) wherein: R1 and R70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; R2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R6 represents a group -CH= as hereinafter described; R73 represents a hydrogen atom or an optional substituent or is absent when R6 represents a methylene group or a group -CH= as hereinafter described; Y represents an optional substituent; n represents 0, 1, 2, 3, or 4; R3 represents a hydrogen atom, or an optionally substituted alkyl group; R74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group; R7 represents a hydrogen atom or an alkyl group; R75 represents an optionally substituted alkyl group; and i) R6 and R71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R72 represents a hydrogen atom; or ii) R71 represents a hydrogen atom or an optionally substituted alkyl or acyl group and R72 represents a hydrogen atom or R71 and R72 each represent radicals so that a double bond is formed between the carbon atoms to which they are attached; and R6 represents an optionally substituted methylene group bonded to the indole moiety thereby to form a tricyclic moiety; or R6 represents an optionally substituted group -CH= bonded to the indole moiety thereby to form an aromatic tricyclic moiety; for use in therapy and as antimitotic reagents are described. Novel hemiasterlins, criamides and geodiamolides are also described.