发明名称 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX
摘要 The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R<3> is formula (II), wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH; R<11> is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, halogen, CF3, amino, nitro, cyano, acylamino, alkoxy, acyl, phenyl, and monocyclic heteroaryl, and one of R<6> and R<7> is hydrogen and the other is pyrrolyl which may be substituted one or more times with substituents selected from halogen, alkyl, phenyl, and alkoxy. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
申请公布号 WO9633192(A1) 申请公布日期 1996.10.24
申请号 WO1996EP01654 申请日期 1996.04.19
申请人 NEUROSEARCH A/S;MEIJI SEIKA KAISHA, LTD.;TEUBER, LENE;WAETJEN, FRANK 发明人 TEUBER, LENE;WAETJEN, FRANK
分类号 C07D401/14;A61K31/415;A61K31/4184;A61K31/44;A61K31/4427;A61K31/443;A61K31/4439;A61K31/501;A61K31/505;A61K31/506;A61P25/00;A61P25/08;A61P25/20;A61P25/22;A61P25/28;A61P43/00;C07D235/06;C07D401/10;C07D403/10;C07D403/14;C07D405/10;C07D405/14;C07D409/10;C07D413/14;C07D417/10;C07D417/14;C07D521/00;(IPC1-7):C07D401/14;A61K31/40 主分类号 C07D401/14
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