发明名称 |
COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS |
摘要 |
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising: (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
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申请公布号 |
CA2218555(A1) |
申请公布日期 |
1996.10.24 |
申请号 |
CA19962218555 |
申请日期 |
1996.04.11 |
申请人 |
NITROMED, INC. |
发明人 |
LETTS, L. GORDON;TAM, SANG W.;GARVEY, DAVID S.;RENFROE, H. BURT |
分类号 |
C07D417/04;A61K31/00;A61K31/19;A61K31/403;A61K31/404;A61K31/405;A61K31/54;A61K31/541;A61K38/00;A61K45/00;A61P1/00;A61P1/04;A61P29/00;A61P43/00;C07C203/00;C07C327/28;C07C381/00;C07D209/28;C07D417/12;C07J41/00;C07K5/02;(IPC1-7):C07D513/04;A61K33/00 |
主分类号 |
C07D417/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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