| 发明名称 |
NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS |
| 摘要 |
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as stromelysin and other matrix metalloproteinases, and also inhibit the production of tumor necrosis factor (TNF), and are therefore useful for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula (I).
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| 申请公布号 |
WO9633176(A1) |
申请公布日期 |
1996.10.24 |
| 申请号 |
WO1996US05410 |
申请日期 |
1996.04.17 |
| 申请人 |
THE DU PONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
XUE, CHU-BIAO;DEGRADO, WILLIAM, F.;DECICCO, CARL, PETER |
| 分类号 |
C07D233/64;A61K31/415;A61K31/4184;A61K31/42;A61K31/421;A61K31/425;A61K31/426;A61P29/00;A61P35/00;C07C233/05;C07C233/11;C07C259/06;C07D233/54;C07D233/68;C07D235/14;C07D235/16;C07D261/08;C07D263/32;C07D277/28;C07D401/12;C07D403/12;C07D413/12;C07D417/12;C07D471/04;(IPC1-7):C07D235/16;C07D487/04;C07D233/61;C07D261/04;C07C239/14 |
主分类号 |
C07D233/64 |
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