The invention relates to a truncated variant of IGF-I having 1-69 of the amino acids of authentic IGF-I (IGF-I(1-69)) and a method of obtaining the truncated IGF-I either by expressing of IGF-I in yeast cells, enzymatic cleavage and thereafter isolating the truncated IGF-I from the medium or by introducing a plasmid encoding for the truncated variant of IGF-I and expressing the truncated variant of IGF-I. The invention also relates to a pharmaceutical composition containing this new truncated variant of IGF-I and to the use of IGF-I(1-69) for the preparation of a medicament.
申请公布号
WO9633216(A1)
申请公布日期
1996.10.24
申请号
WO1996SE00520
申请日期
1996.04.19
申请人
PHARMACIA AB;ERIKSSON, ROLF;JOHANSSON, STIG;ROENNHOLM, HARRIET;SKOTTNER, ANNA;SONESSON, KARIN
发明人
ERIKSSON, ROLF;JOHANSSON, STIG;ROENNHOLM, HARRIET;SKOTTNER, ANNA;SONESSON, KARIN