METHODS AND APPARATUS FOR THE GENERATION OF CHEMICAL LIBRARIES

摘要

Method and apparatus for generation of chemical libraries are described. The apparatus includes a reaction block (140) which supports replaceable reaction chambers. Each reaction block is fitted with four sets of twelve reaction chambers. Reaction chambers are provided with s-shaped trap tubes which run into drain tubes. The reaction block is provided with gas lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station (300) secures registration of reaction blocks and introduces gases and liquids into the reaction blocks (140). An inert atmosphere is maintained in the reaction block by a top and an optional bottom seals. A needle (20) pipettes reagents from reagent containers (44) into reaction chambers. A container rack (90) keeps reagent containers securely in place.