NOVEL THERAPEUTIC BINDING MOLECULE COMPLEXES

摘要

Structures that bind to a selected target are prepared having two or more different effector molecules joined to each other by a joining component. At least one of the effector molecules such as an antibody binds to the target and at least one of the other effector molecules such as an enzyme is therapeutic. The joining component may be a liposome, protein, dendrimer polymer or complementary nucleic acid chains. The joining component may be of sufficient length and/or flexibility to permit the therapeutic molecule to physically interact with the target at the same time as the binding molecule binds with the target. The structures may be used in disease treatment, immunoassays and sensors. For in vivo genetic manipulation of cells, the liposome joining component is filled with a plurality of genetic manipulation complexes that contain a polynucleotide having a sequence for recombination and a binding site, a DNA binding protein bound to the binding site and a motor protein conjugated to the polynucleotide. Prophospholipase may be on the surface of the liposome, and when activated cleaves the liposome to release the complex.