| 摘要 |
<p>Title cpds. of formula (I):- (where R1 and R2 are H or lower alkyl or alkoxy or R1 + R2 is methylenedioxy; R3 is H, an opt. unsatd. is not >12C aliphatic residue opt. substd. by CN, COOH, carbamoyl, benzoyloxy, pyridoxyloxy, lower acyloxy, alkoxycarbonyl, alkylamino or dialkylamino, a 5- or 6-membered cycloaliphatic residue opt. substd. by lower alkyl, aryl-(1-3C alkyl) or furfuryl and R4 is H, or NR3R4 is an opt. unsatd. 5- or 6-membered heterocyclic ring opt. interrupted by N or O and opt. substd. by lower alkyl; and R5 is an opt. substd. 1-12C opt. unsatd. aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic residue), which have excellent activity against amoebae as well as against trichomonads and are also active against gram-negative organisms such as E. coli and Salmonellae.</p> |
