Phosphonates, biphosphonates and pharmaceutical compositions containing them

摘要

There are provided novel derivatives of certain phosphonates and bisphosphonates, and especially of compounds of the pamidronate and alendronate type. More particularly, the invention relates to aminoacyl and peptidyl derivatives of such compounds. Furthermore, the invention relates to pharmaceutical compositions which contain as active ingredient an adequate quantity of such novel compounds. The novel pharmaceutical compositions are characterized by improved absorption in the human body after application by the oral route.