发明名称 |
Expression library immunization |
摘要 |
A general method for vaccinating against any pathogen is presented. The method utilizes expression library immunization, where an animal is inoculated with an expression library constructed from fragmented genomic DNA of the pathogen. All potential epitopes of the pathogen's proteins are encoded in its DNA, and genetic immunization is used to directly introduce one or more expression library clones to the immune system, producing an immune response to the encoded protein. Inoculation of expression libraries representing portions of the Mycoplasma pulmonis genome was shown to protect mice from subsequent challenge by this natural pathogen. Protection against Listeria. |
申请公布号 |
AU5384396(A) |
申请公布日期 |
1996.10.23 |
申请号 |
AU19960053843 |
申请日期 |
1996.04.03 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
STEPHEN A JOHNSTON;MICHAEL A. BARRY;WAYNE C LAI |
分类号 |
A01K67/027;A61K31/70;A61K39/00;A61K39/02;A61K48/00;A61P37/04;C07K14/00;C07K14/195;C07K14/295;C07K14/30;C07K14/61;C07K16/00;C12N15/09;C12N15/87;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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