摘要 |
New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydroxyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with (+)-camphorsulfonic acid, or with a salt thereof, the (+),(-)-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and demethylation, by means of concentrated solutions of haloid acids, of the (+)-2-amino-3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.
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