发明名称 ALPHA-TOCOPHEROL DERIVATIVE
摘要 PURPOSE: To obtainα-tocopherol rivative useful as e.g. an antisterility vitamin, lipid depressant, cell aging-proofing agent, antioxidant, consisting of 2,5,7,8- tetramethyl-2-(4',8',12'-trimethyltrideca-11'-enyl)-6-chromanol. CONSTITUTION: This newα-tocopherol derivative as 2,5,7,8-tetramethyl-2-(4',8',12'- trimethyltrideca-11)-enyl)-6-chromanol is expressed by the formula, and useful as e.g. an antisterility vitamin, blood lipid depressant, blood circulation promoter, active oxygen scavenger, cell aging-proofing agent, and antioxidant. This compound of the formula is obtained by the following process: a tocopherol concentrate obtained by molecular distillation of palm crude oil is subjected to a glass column packed with silica get as adsorbent followed by elution with an n-hexane/n-butyl ether system and then with an n-hexane/2-propanol system each as mobile phase, and the eluted product is purified by dispensing high- performance liquid chromatography.
申请公布号 JPH08277282(A) 申请公布日期 1996.10.22
申请号 JP19950081545 申请日期 1995.04.06
申请人 EISAI CO LTD 发明人 MATSUMOTO AKIRA;KIJIMA SHIZUMASA
分类号 C07D311/72;A61K31/352;A61K31/355;A61P3/06;A61P9/08;A61P9/10;A61P13/02;A61P15/00;C09K15/08;(IPC1-7):C07D311/72 主分类号 C07D311/72
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