发明名称 |
Diltiazem controlled release formulation |
摘要 |
A once-a-day controlled release diltiazem formulation is described which includes: (a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and (b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and (c) a unit dose containment system.
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申请公布号 |
US5567441(A) |
申请公布日期 |
1996.10.22 |
申请号 |
US19950409449 |
申请日期 |
1995.03.24 |
申请人 |
ANDRX PHARMACEUTICALS INC. |
发明人 |
CHEN, CHIH-MING |
分类号 |
A61K9/52;A61K9/50;A61K9/58;A61K31/55;A61K31/554;A61K47/30;(IPC1-7):A61K9/58;A61K9/60;A61K9/62 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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