Imidazole, Triazole and tetrazole derivatives

摘要

PCT No. PCT/GB93/01495 Sec. 371 Date Jan. 24, 1995 Sec. 102(e) Date Jan. 24, 1995 PCT Filed Jul. 15, 1993 PCT Pub. No. WO94/02477 PCT Pub. Date Feb. 3, 1994 <IMAGE> (I) <IMAGE> (a) <IMAGE> (i) <IMAGE> (ii) <IMAGE> (iii) Imidazole, triazole and tetrazole derivatives of formula (I) are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated, wherein the broken circle represents two non-adjacent double bonds in any position in the five-membered ring; two, three or four of V, W, X, Y and Z represent nitrogen and the remainder represent carbon provided that, when two of V, W, X, Y and Z represent nitrogen and the remainder represent carbon, then the said nitrogen atoms are in non-adjacent positions within the five-membered ring; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; F represents a group of formula (a); U represents nitrogen or C-R2; B represents oxygen, sulphur or N-R3; R1 represents a group of formula (i), (ii) or (iii).