发明名称 |
Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
摘要 |
The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.
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申请公布号 |
US5567859(A) |
申请公布日期 |
1996.10.22 |
申请号 |
US19940292803 |
申请日期 |
1994.08.09 |
申请人 |
CYTRX CORPORATION |
发明人 |
EMANUELE, R. MARTIN;BALASUBRAMANIAN, MANNARSAMY;ALLAUDEEN, HAMEEDSULTHAN S. |
分类号 |
A61K31/765;A61K31/77;A61K45/06;A61K47/48;C08G65/08;C08G65/26;C08G65/30;(IPC1-7):C07C43/11 |
主分类号 |
A61K31/765 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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