发明名称 |
Texaphyrins and uses thereof |
摘要 |
A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.
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申请公布号 |
US5567687(A) |
申请公布日期 |
1996.10.22 |
申请号 |
US19940310501 |
申请日期 |
1994.09.21 |
申请人 |
UNIVERSITY OF TEXAS;PHARMACYCLICS, INC. |
发明人 |
MAGDA, DARREN;SESSLER, JONATHAN L.;IVERSON, BRENT;JANSEN, PETRA L.;WRIGHT, MEREDITH;MODY, TARAK D.;HEMMI, GREGORY W. |
分类号 |
A61K41/00;A61K49/00;A61K49/06;A61K49/08;A61K51/04;A61L2/00;B01J31/02;B01J31/16;B01J31/18;C07D487/22;C07H21/00;C12N15/113;(IPC1-7):C07D487/22 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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