摘要 |
Certain 1-heteroaryl-3-acyl-2-oxindoles wherein the acyl-substituent is thenoyl, furoyl, benzoyl or substituted benzoyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflam-matory agents in mammals. (I) ¢wherein R1 is thienyl, furyl or 2-thiazolyl; R2 is thienyl, furyl or (in which X is H, F, Cl C1-4alkyl, C1-4alkoxy, C1-4alkylthio, nitro of CF3, and Y is H, F, or Cl); and R3 and R4 may be the same or different and each are H, F, Cl, Br, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, nitro or CF3!.
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