| 发明名称 |
PHARMACEUTICAL COMPOSITIONS COMPRISING SYNTHETIC PEPTIDE COPOLYMER FOR PREVENTION OF GVHD |
| 摘要 |
Pharmaceutical compositions comprising as active ingredient a synthetic random copolymer of average molecular weight of about 4,000-12,000, preferably 6,0008,000, said copolymer consisting of glutamic acid (Glu), lysine (Lys), alanine (Ala) and tyrosine (Tyr) residues in a relative molar ratio of 1.4-2.1 parts of Glu to 3.2-5.0 parts of Lys to 4.0-6.6 parts of Ala to 1.0 parts of Tyr (herein GLAT copolymers), can be used in a method for prevention and treatment of graft-versus-host disease in patients in the course of bone marrow and organ transplantation.
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| 申请公布号 |
CA2215389(A1) |
申请公布日期 |
1996.10.17 |
| 申请号 |
CA19962215389 |
申请日期 |
1996.04.15 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
CHAO, NELSON J.;ARNON, RUTH;TEITELBAUM, DVORA;AHARONI, RINA;SELA, MICHAEL;SCHLEGEL, PAUL G. |
| 分类号 |
A61K38/00;A61K31/785;A61P37/00;A61P43/00;C07K7/08;C07K14/00;C08G69/10;(IPC1-7):A61K38/16 |
主分类号 |
A61K38/00 |
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