ARYL GLYCINAMIDE DERIVATIVES, METHODS OF PRODUCING THESE SUBSTANCES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS

摘要

The invention concerns novel aryl glycinamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof, the symbols having the following meanings: R<1> and R<2> together with the nitrogen atom to which they are bound form a ring of formula (II) shown in which p is 2 or 3 and X stands for oxygen, N(CH2)nR<6> or CR<7>R<8>; and R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, Ar and n have the meanings indicated in the description. The invention also concerns the production and use of these substances. The novel compounds are valuable neurokinin (tachykinin) antagonists.