SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS

摘要

Indol-3-ylmethylene-2-oxindole derivatives having general formula (I), wherein one or two of R, R1, R2 and R3 are a substituent selected independently from: a) a -X-(CH2)m-NH2, -X-(CH2)m-NR4R5, or -X-(CH2)m-NHR6 group, b) a -NHC(NH)NH2, -NHC(NH)NR4R5, -NHC(NH)NHR6, -N=CH-NHz, -N=CH-NR4R5 or -N=CH-NHR6 group, c) a -X-(CH2)m-COR7 group, d) a -CORa or COR8 group, e) a -Y-CO-Y'-R9 group, f) a -NHR6 or -NHR10 group, and the pharmaceutically acceptable salts of salt forming compounds of formula (I), have tyrosine kinase inhibiting activity.