4-AMINO-5-OXY-2,6,6-TRIMETHYL-2-CYCLOHEPTENE COMPOUNDS

摘要

4-Amino-5-oxy-2,6,6-trimethyl-2-cycloheptene compounds represented by general formula (I), pharmacologically acceptable salts thereof, or solvates of these wherein R<1> and R<2> independently represent each hydrogen, optionally substituted alkyl or phenyl optionally having hydroxy, lower alkoxy, amino, nitro, carboxy, lower alkoxycarbonyl or halogeno on its ring, or R<1> and R<2> together with the nitrogen atom may form a nitrogen-containing heterocycle; R<3> represents hydrogen, lower alkyl or lower aliphatic acyl; and W represents oxo, oxime or oxime ether. The compounds exert effects on a rat peripheral embolism model, a spontaneously hypertensive rat and a histamine-induced airway constriction model, which indicates that they are useful as a remedy for hypertension, peripheral embolism or bronchial asthma.