| 摘要 |
<p>Disclosed and claimed are non-immunogenic biocompatible macromolecular sheet composition pouches therefrom and methods of making and using the same. The composition is formed from a cellulosic membrane, a binding moiety having a plurality of functional groups, and a glycosaminoglycan (GAG). The binding moiety has the formula of R1-X-R2 wherein R?1 and R2¿ are the same or different. The binding moiety, through functional groups binds the cellulosic membrane with the glycosaminoglycan. R1 is covalently bound to a carbon or an oxygen of the cellulosic membrane. R2 is covalently bound to a carbon, an oxygen, or a nitrogen of the glycosaminoglycan. The binding moiety can be bis-oxyrane, butanediol-diglycidyl ether (BDE), or divinyl sulfone. The cellulosic membrane can be a cellulosic membrane, partially acetlylated cellulose and a copolymer of hydroxyethyl-methacrylate with methyl methacrylate, abbreviated as HEMA-MMA. The non-immunogenic biocompatible macromolecular sheet composition can be formed into a pouch to encapsulate cells, tissues, pharmaceuticals, or biological metabolic products. In addition, the non-immunogenic biocompatible macromolecular sheet composition can also be used as a skin graft or a skin substitute. Further, these non-immunogenic biocompatible macromolecular sheet composition can also be used as a surface to culture cells in vitro.</p> |
