INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS

摘要

This invention relates to new indole derivatives of formula (I), wherein R<1> is hydrogen, halogen, nitro, carboxy, protected carboxy, acyl, etc., R<2> is hydrogen, halogen, lower alkenyl, acyl, etc., R<3> is lower alkenyl or lower alkyl, both of which are optionally substituted with aryl optionally substituted with one or more substituent(s) selected from the group consisting of halogen, aryl, lower alkoxy, etc., and R<4> is carboxy, protected carboxy, acyl, etc., in addition to their significances above, R<1> and R<2>, together with the carbon atoms to which they are attached, represent a 4- to 7-membered carboxylic ring optionally substituted with oxo, or its pharmaceutically acceptable salt, which is useful as a medicament; and to new use of cyclic nucleotide-PDE inhibitors.