发明名称 |
Immunoglobulin for treatment of respiratory syncytial virus |
摘要 |
A process for identifying plasma samples containing effective antibody titers for the treatment and/or prophylaxis of infections caused by a respiratory virus. The process comprises contacting a plasma sample containing antibodies against a respiratory virus with the respiratory virus. The mixture of plasma sample and virus is then contacted with a plurality of cells. The remaining non-neutralized virus in the sample is then determined through an immunoassay following replication of the virus in the cells. Plasma samples which, at a preselected minimum antibody titer value, prevent viral replication in the cells, are then selected. Plasma from which the selected samples were derived are then pooled to provide an immunoglobulin preparation having increased effectiveness in the prophylaxis and/or treatment of infections caused by the respiratory virus. |
申请公布号 |
AU6067896(A) |
申请公布日期 |
1996.10.17 |
申请号 |
AU19960060678 |
申请日期 |
1996.07.24 |
申请人 |
MASSACHUSETTS HEALTH RESEARCH INSTITUTE, INC. |
发明人 |
GEORGE R SIBER;JEANNE LESZCZYNSKI |
分类号 |
A61K39/395;G01N33/569 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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