Bifunctional thrombin inhibitors bearing highly truncated fi brinogen recognition exosite binding component

摘要

The present invention relates to peptide derivatives useful in the treatment and prophylaxis of vascular disease related to thrombosis. The peptide derivatives are based on the amino acid sequence of Hirudin having a general formula: A-L-E, wherein A is an inhibitor of the active site of the enzyme thrombin; L is a linker; and E is a fibrinogen recognition exosite binding moiety comprising 3 to 5 amino acids having binding affinity for the fibrinogen recognition exosite of thrombin.