| 摘要 |
A computer-based organ perfusion apparatus is described which is capable of perfusing organs (1) at near-normal temperatures with blood or other oxygen-carrying substances. The apparatus permits organ viability to be evaluated by on-line measurements of physiological performance. Embodiments of the apparatus use a computer-driven blood pump (30) to allow physiological perfusion conditions to be established. The apparatus includes provisions (48) for the replacement of lost circulating volume and for the infusion of nutrients, drugs, and altered perfusates to assist in maintenance or recovery of organs. The apparatus may further sense perfusate gas tensions, pH, and temperature without electrical cross-interference (15 and 16), automatically measure production rates of urine, bile, pancreatic duct secretions, or other physiological exudations (8), and determine organ blood or perfusate flow rates, vascular resistance, and organ edema (4). |
