Use of surfactants for introducing genetic material into lun g cells

摘要

A process for introducing genetic material (wich may be contained in an expression vehicle such as an adenoviral vector or retroviral vector) into lung cells which comprises contacting the lung cells with the genetic material and at least one surfactant. The at least one surfactant may be a lipid-containing surfactant. Such process provides for improved transduction of the genetic material into lung cells, as well as for transduction of both large airway (trachea and bronchus) cells and lung parenchymal cells.